How do i set up my macros to to be aimed at a target.
Example: envenom sword (venom)
strike @target (bodypart)

What client do you use?

I use Mush client

change to zmud and i an tell you all about it.

Use aliases. Setup an alias with pattern "t *" and choose "Send to Variable" and specify %1 as the value to send, and put "target" in the Variable field.

Make a second alias for your attack, check "Expand variables," and make the command something along the lines of "strike @target head"...

(And I don't recommend envenoming before every attack, since your poisons won't hit every time anyway. Your weapon will fill up with poisons eventually.)

(And, Murphy, quit telling people to switch to zMUD. )